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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

Compound VII     5-[5-[2-chloro-4-(4,5- dihydro-1,3-oxazol-2...

Synonyms: CHEMBL6444, AG-J-95097, SureCN9666735, CHEBI:47727, Win-53338, ...
 
 
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High impact information on Isoxazole, 5-(5-(2-chloro-4-(4,5-dihydro-2-oxazolyl)phenoxy)pentyl)-3-methyl-

  • Compound VII was shown to be noncompetitive (Ki = 2.4 X 10(-7) mol/l) [1].
  • 7 beta-[2-(2-Aminothiazol-4-yl)acetamido]-7 alpha-methoxycephalosporins were synthesized both by acylation of the 7 beta-amino-7 alpha-methoxycephalosporin compound (VIII) and a new direct acyl-exchange reaction of 7 alpha-methoxy-7 beta-phosphoramido compound (VII) [2].
 

Biological context of Isoxazole, 5-(5-(2-chloro-4-(4,5-dihydro-2-oxazolyl)phenoxy)pentyl)-3-methyl-

  • Among compounds that we synthesized, benzyloxycarbonyl (Z)-Phe-His-Leucinal (compound V), Z-Pro-Phe-His-Leucinal (Compound IV) and Z-[3-(1'-naphthyl)Ala]-His-Leucinal (compound VII) markedly inhibited human renin (IC50, 7.5 X 10(-7), 3.2 X 10(-7) and 8.0 X 10(-8) mol/l, respectively) [1].

References

  1. Highly potent and specific inhibitors of human renin. Kokubu, T., Hiwada, K., Sato, Y., Iwata, T., Imamura, Y., Matsueda, R., Yabe, Y., Kogen, H., Yamazaki, M., Iijima, Y. Biochem. Biophys. Res. Commun. (1984) [Pubmed]
  2. Synthesis and structure-activity relationships of 7 beta-[2-(2-aminothiazol-4-yl)acetamido]-cephalosporin derivatives. II. Synthesis and antibacterial activity of 7 beta-[2-(2-aminothiazol-4-yl)acetamido]-7 alpha-methoxycephalosporins. Ochiai, M., Morimoto, A., Matsushita, Y., Kida, M. J. Antibiot. (1980) [Pubmed]
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