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Chemical Compound Review

CCRIS 4296     6-(2-ethylhexoxy)-6-oxo- hexanoic acid

Synonyms: LS-117, AG-F-53582, CTK4I7289, AC1L2G2D, 4337-65-9, ...
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High impact information on Mono-2-ethylhexyl adipate

  • In rat and mouse hepatocytes, the parent compound (DEHA) had no effect on peroxisomal beta-oxidation, but primary metabolites of DEHA, mono (2-ethylhexyl) adipate (MEHA) and 2-ethylhexanol (EH), were approximately equipotent in PCO induction (5-fold at 0.5 mM final concentration) [1].


  1. Identification of the proximate peroxisome proliferator(s) derived from di (2-ethylhexyl) adipate and species differences in response. Cornu, M.C., Lhuguenot, J.C., Brady, A.M., Moore, R., Elcombe, C.R. Biochem. Pharmacol. (1992) [Pubmed]
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