Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

E-Endoxifen 4-[(E)-1-[4-(2- methylaminoethoxy)phenyl]- 2...

Synonyms: SureCN8655920, NSC-750182, NSC750182, FT-0669525, AC1MI0CB, ...

Hellmann-Blumberg, U. et al., Robinson, S.P. et al.

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Disease relevance of Phenol, 4-(1-(4-(2-(methylamino)ethoxy)phenyl)-2-phenyl-1-butenyl)-

4-Hydroxy-N-desmethyltamoxifen was detected in serum from six out of 10 breast cancer patients receiving 10 mg bid of tamoxifen [1].

Analytical, diagnostic and therapeutic context of Phenol, 4-(1-(4-(2-(methylamino)ethoxy)phenyl)-2-phenyl-1-butenyl)-

At least two distinct adduct spots resulting from 4-hydroxy-N-desmethyltamoxifen (metabolite Bx) were detected by 32P postlabeling and thin layer chromatography [2].

References

Implications of tamoxifen metabolism in the athymic mouse for the study of antitumor effects upon human breast cancer xenografts. Robinson, S.P., Langan-Fahey, S.M., Jordan, V.C. European journal of cancer & clinical oncology. (1989) [Pubmed]
Intrinsic reactivity of tamoxifen and toremifene metabolites with DNA. Hellmann-Blumberg, U., Cartner, M.G., Wurz, G.T., DeGregorio, M.W. Breast Cancer Res. Treat. (1998) [Pubmed]

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