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Chemical Compound Review:

Trehazolin (1R,2S,3S,4S,5S)-2- (hydroxymethyl)-7-[[(2S...

Synonyms: Trehalostatin, AC1MIXKU, 132729-37-4

Kyosseva, S.V. et al., Wegener, G. et al., Zeng, Y.C. et al., Sugiyama, Y. et al.

Wegener, Tschiedel, Schlöder, Ando,

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Disease relevance of Trehalostatin

Trehazolin (1) is a trehalase inhibitor produced by Micromonospora coriacea [1].

High impact information on Trehalostatin

Trehazolin, an antibiotic pseudosaccharide, inhibits locust flight muscle trehalase with apparent K(i)- and EC(50) values of 10(-8) mol l(-1) and 10(-7) mol l(-1), respectively [2].
On the other hand, the other processing glucosidase, glucosidase II, is sensitive to inhibition by australine, but not by trehazolin [3].
We also found that trehazolin is a very powerful and quite specific inhibitor against purified pig kidney trehalase, giving an IC50 value of 1.9 x 10(-8) M [4].
However, even at concentrations of 200 micrograms/ml, trehazolin did not inhibit the rat intestinal maltase or sucrase, yeast alpha-glucosidase or almond beta-glucosidase [4].

References

Biosynthesis of the trehalase inhibitor trehazolin. Sugiyama, Y., Nagasawa, H., Suzuki, A., Sakuda, S. J. Antibiot. (2002) [Pubmed]
The toxic and lethal effects of the trehalase inhibitor trehazolin in locusts are caused by hypoglycaemia. Wegener, G., Tschiedel, V., Schlöder, P., Ando, O. J. Exp. Biol. (2003) [Pubmed]
Purification to homogeneity and properties of plant glucosidase I. Zeng, Y.C., Elbein, A.D. Arch. Biochem. Biophys. (1998) [Pubmed]
Inhibitors of pig kidney trehalase. Kyosseva, S.V., Kyossev, Z.N., Elbein, A.D. Arch. Biochem. Biophys. (1995) [Pubmed]

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