Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

gemsa (2S)-2-[2- (diaminomethylideneamino) ethylsu...

Synonyms: DB04489, AC1L9IZ6, 1h8l, GEM, 185833-EP2278973A1, ...

Von dem Borne, P.A. et al., Stone, T.E. et al., Chen, Y.Y. et al.

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High impact information on GUANIDINOETHYL MERCAPTOSUCCINIC ACID

The lysis time was decreased twofold when TAFI was absent, when TAFI activation was inhibited by anti-TAFI antibodies, or when activated TAFI was inhibited by the competitive inhibitor (2-guanidinoethylmercapto)succinic acid [1].
The enzyme activity was strongly inhibited by the Arg analog (2-guanidinoethylmercapto)succinic acid and 1,10-phenanthroline [2].
Its sensitivity to guanidinoethyl-mercaptosuccinic acid, and its molecular mass, make this enzyme a good candidate to be the insect equivalent of the mammalian CPE [3].

References

Thrombin-mediated activation of factor XI results in a thrombin-activatable fibrinolysis inhibitor-dependent inhibition of fibrinolysis. Von dem Borne, P.A., Bajzar, L., Meijers, J.C., Nesheim, M.E., Bouma, B.N. J. Clin. Invest. (1997) [Pubmed]
CPG70 is a novel basic metallocarboxypeptidase with C-terminal polycystic kidney disease domains from Porphyromonas gingivalis. Chen, Y.Y., Cross, K.J., Paolini, R.A., Fielding, J.E., Slakeski, N., Reynolds, E.C. J. Biol. Chem. (2002) [Pubmed]
Purification and characterization of the Manduca sexta neuropeptide processing enzyme carboxypeptidase E. Stone, T.E., Li, J.P., Bernasconi, P. Arch. Insect Biochem. Physiol. (1994) [Pubmed]

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