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Chemical Compound Review

AG-L-65199     1-acetyloxyethyl (6R,7S)-3...

Synonyms: CTK8F8544, AC1L2I23, cefuroxime axetil
 
 
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High impact information on CXM-AX

  • In phosphate buffer, the major degradation product was the Delta2-cephalosporin (CAT = 61%; CAE = 74%; CPD = 85%), while in intestinal juice it was the Delta3-cephalosporin (CAT = 86%; CAE = 75%; CPD = 87%) [1].

References

  1. Stability of cephalosporin prodrug esters in human intestinal juice: implications for oral bioavailability. Stoeckel, K., Hofheinz, W., Laneury, J.P., Duchene, P., Shedlofsky, S., Blouin, R.A. Antimicrob. Agents Chemother. (1998) [Pubmed]
 
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