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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

AG-J-94770     ethyl2-[4-(7-thia-10- azabicyclo[4.4.0]dec...

Synonyms: SureCN14191674, AC1L1JSO, CTK6F7365, DB08540, sdz 880-061
 
 
 
 
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Disease relevance of 2-[4-(2H-1,4-BENZOTHIAZINE-3-YL)-PIPERAZINE-1-LY]-1,3-THIAZOLE-4-CARBOXYLIC ACID ETHYLESTER

  • Since it is assumed that uncoating requires virion instability and/or flexibility, the finding that SDZ 880-061 has only a marginal effect on uncoating may be due to the fact that it does not completely fill the hydrophobic pocket [1].

References

  1. Synthesis and activity of piperazine-containing antirhinoviral agents and crystal structure of SDZ 880-061 bound to human rhinovirus 14. Oren, D.A., Zhang, A., Nesvadba, H., Rosenwirth, B., Arnold, E. J. Mol. Biol. (1996) [Pubmed]
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