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Chemical Compound Review

AC1NQSSP     2-morpholin-4-yl-6- thianthren-1-yl-pyran-4...

Synonyms: cc-73, PubChem22474, S1092_Selleck, CHEMBL222102, AG-G-08325, ...
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High impact information on AIDS284437

  • Through screening a small molecule compound library developed for the phosphatidylinositol 3'-kinase-like kinase family, we identified an ATP-competitive inhibitor, 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one (KU-55933), that inhibits ATM with an IC(50) of 13 nmol/L and a Ki of 2.2 nmol/L [1].


  1. Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM. Hickson, I., Zhao, Y., Richardson, C.J., Green, S.J., Martin, N.M., Orr, A.I., Reaper, P.M., Jackson, S.P., Curtin, N.J., Smith, G.C. Cancer Res. (2004) [Pubmed]
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