Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Alipza (E,3R,5S)-7-[2-cyclopropyl-4- (4...

Synonyms: Flovas, Livazo, Pitava, Itavastatin, Nisvastatin, ...

Deng, J.W. et al.

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Associations of Itavastatin with other chemical compounds

The greater decrease in the transport activity for pitavastatin in SLCO1B1*15 variant compared with SLCO1B1*1a was, however, associated with the greater effect on the pharmacokinetics of pitavastatin compared with pravastatin in relation to the SLCO1B1 genetic polymorphism [1].

References

The effect of SLCO1B1*15 on the disposition of pravastatin and pitavastatin is substrate dependent: the contribution of transporting activity changes by SLCO1B1*15. Deng, J.W., Song, I.S., Shin, H.J., Yeo, C.W., Cho, D.Y., Shon, J.H., Shin, J.G. Pharmacogenet. Genomics (2008) [Pubmed]

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