Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Epitomax

Synonyms: Epitoma, Topamac, Topamax, Topimax, Topomax, ...

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Disease relevance of Epitomax

Topiramate reduced binge eating days/week (-3.5 +/- 1.9 vs. -2.5 +/- 2.1), binge episodes/week (-5.0 +/- 4.3 vs. -3.4 +/- 3.8), weight (-4.5 +/- 5.1 kg vs. .2 +/- 3.2 kg), and BMI (-1.6 +/- 1.8 kg/m2 vs. .1 +/- 1.2 kg/m2) compared with placebo (p < .001) [1].
Sustained benefit was reported after discontinuation of topiramate, although number of migraine days did increase [2].

References

Topiramate for the treatment of binge eating disorder associated with obesity: a placebo-controlled study. McElroy, S.L., Hudson, J.I., Capece, J.A., Beyers, K., Fisher, A.C., Rosenthal, N.R. Biol. Psychiatry (2007) [Pubmed]
Cessation versus continuation of 6-month migraine preventive therapy with topiramate (PROMPT): a randomised, double-blind, placebo-controlled trial. Diener, H.C., Agosti, R., Allais, G., Bergmans, P., Bussone, G., Davies, B., Ertas, M., Lanteri-Minet, M., Reuter, U., Sánchez Del Río, M., Schoenen, J., Schwalen, S., van Oene, J. Lancet. Neurol (2007) [Pubmed]

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