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Chemical Compound Review:

fluorofumarate (Z)-2-fluorobut-2-enedioic acid

Synonyms: AC1NTOSN, NSC-403467, NSC403467, CPD0-2038, NSC 403467, ...

Kim, S.C. et al., Garrard, L.J. et al., Marletta, M.A. et al.

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High impact information on Monofluorofumarate

Substrate-induced inactivation of argininosuccinate lyase by monofluorofumarate and difluorofumarate [1].
Stereochemical studies on the hydration of monofluorofumarate and 2,3-difluorofumarate by fumarase [2].
The interaction of monofluorofumarate with adenylosuccinate lyase [3].
A similar reaction scheme was also observed when AICAR was utilized as a cosubstrate with monofluorofumarate [3].

Associations of Monofluorofumarate with other chemical compounds

The initial reaction rate when 1.0 mM monofluorofumarate and 1.0 mM AMP were used as substrates with adenylosuccinate lyase was only 1.4% of the rate when 1.0 mM fumarate was used [3].

References

Substrate-induced inactivation of argininosuccinate lyase by monofluorofumarate and difluorofumarate. Garrard, L.J., Mathis, J.M., Raushel, F.M. Biochemistry (1983) [Pubmed]
Stereochemical studies on the hydration of monofluorofumarate and 2,3-difluorofumarate by fumarase. Marletta, M.A., Cheung, Y.F., Walsh, C. Biochemistry (1982) [Pubmed]
The interaction of monofluorofumarate with adenylosuccinate lyase. Kim, S.C., Raushel, F.M. J. Enzym. Inhib. (1988) [Pubmed]

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