Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

pyrimidin-5-ol pyrimidin-5-ol

Synonyms: zlchem 890, PubChem20799, SureCN147677, AG-E-91510, AG-K-61271, ...

Ji, H.F. et al., Purmal, A.A. et al.

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High impact information on pyrimidin-5-ol

5-Hydroxypyrimidine deoxynucleoside triphosphates are more efficiently incorporated into DNA by exonuclease-free Klenow fragment than 8-oxopurine deoxynucleoside triphosphates [1].
Furthermore, the potential of the active center of metabolites of folates, 4-hydroxypyrimidine (4-HP), as lead antioxidant, was evaluated by comparing the BDEs and IPs of 4-HP with those of 5-hydroxypyrimidine (5-HP) [2].

References

5-Hydroxypyrimidine deoxynucleoside triphosphates are more efficiently incorporated into DNA by exonuclease-free Klenow fragment than 8-oxopurine deoxynucleoside triphosphates. Purmal, A.A., Kow, Y.W., Wallace, S.S. Nucleic Acids Res. (1994) [Pubmed]
A theoretical study on the structure-activity relationships of metabolites of folates as antioxidants and its implications for rational design of antioxidants. Ji, H.F., Tang, G.Y., Zhang, H.Y. Bioorg. Med. Chem. (2005) [Pubmed]

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