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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

L-Leucinamide,N,N-dimethyl-L- phenylalanyl-(3S)-3-hydroxy-L-leucyl-N- (2-(4-hydroxyphenyl)ethenyl)-, cyclic (2-3)-ether     N-[(10E)-7-butan-2-yl-5,8- dioxo-3-propan-2...

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High impact information on Frangufoline

  • On the basis of these results, a possible mechanism for metabolic conversion of frangufoline to M1 was proposed, in which oxidation of the vinyl group and enzyme-catalyzed hydrolysis of the adjacent amide bond, possibly by B-esterase-like enzyme, proceed in a concerted manner [1].

References

  1. Metabolic cleavage of frangufoline in rodents: in vitro and in vivo study. Suh, D.Y., Kim, Y.C., Kang, Y.H., Han, Y.N., Han, B.H. J. Nat. Prod. (1997) [Pubmed]
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