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Chemical Compound Review:

AC1LCVA4 (2S)-2-[[(2S)-2- dimethylamino-3-methyl...

Synonyms: SureCN3069905, D01919, Soblidotin (JAN/INN)

Natsume, T. et al., Watanabe, J. et al., Natsume, T. et al.

Watanabe, Minami, Kobayashi, Natsume, Watanabe, Horiuchi, Kobayashi,

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Disease relevance of Tzt 1027

Antitumor activity of TZT-1027 (Soblidotin) against vascular endothelial growth factor-secreting human lung cancer in vivo [1].

High impact information on Tzt 1027

BACKGROUND: TZT-1027 (Soblidotin), a newly synthesized dolastatin 10 derivative that depolymerizes microtubules, has potent antitumor activity [2].

Analytical, diagnostic and therapeutic context of Tzt 1027

BACKGROUND: TZT-1027 (Soblidotin), an antimicrotubule drug, has shown potent antitumor efficacy in various antitumor models, and has entered into phase I clinical trials [3].

References

Antitumor activity of TZT-1027 (Soblidotin) against vascular endothelial growth factor-secreting human lung cancer in vivo. Natsume, T., Watanabe, J., Koh, Y., Fujio, N., Ohe, Y., Horiuchi, T., Saijo, N., Nishio, K., Kobayashi, M. Cancer Sci. (2003) [Pubmed]
Antitumor activity of TZT-1027 (Soblidotin). Watanabe, J., Minami, M., Kobayashi, M. Anticancer Res. (2006) [Pubmed]
Combination effect of TZT-1027 (Soblidotin) with other anticancer drugs. Natsume, T., Watanabe, J., Horiuchi, T., Kobayashi, M. Anticancer Res. (2006) [Pubmed]

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