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Chemical Compound Review:

Lodaxaprina 1-[6-(2- chlorophenyl)pyridazin-3...

Synonyms: Lodaxaprine, Lodaxaprium, CHEMBL122135, SureCN2109167, CM-40907, ...

Schaffler, K. et al., Chambon, J.P. et al.

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Disease relevance of Lodaxaprine

In naturally photosensitive Senegalese Papio-papio baboons CM 40907 antagonized myoclonus and cortical paroxysmal discharges [1].

High impact information on Lodaxaprine

A randomized, double-blind crossover study was performed with three different acute oral dosages of CM 40907 (3-(4-hydroxypiperidyl)-6-(2'-chlorophenyl)-pyridazine) (600, 900 and 1200 mg), a newly developed anticonvulsant drug, vs acetylsalicylic acid (ASA, 1000 mg) and placebo in 12 male healthy volunteers to check analgesic potency [2].

References

CM 40907: a structurally novel anticonvulsant in mice, rats and baboons. Chambon, J.P., Brochard, J., Hallot, A., Heaulme, M., Brodin, R., Roncucci, R., Biziere, K. J. Pharmacol. Exp. Ther. (1985) [Pubmed]
Analgesic potency of a new anticonvulsant drug versus acetylsalicylic acid via laser somatosensory evoked potentials. Randomized placebo-controlled double-blind (5-way) crossover study. Schaffler, K., Wauschkuhn, C.H., Gierend, M. Arzneimittel-Forschung. (1991) [Pubmed]

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