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Chemical Compound Review

Mellitene     1,2,3,4,5,6-hexamethylbenzene

Synonyms: CHEMBL16347, AGN-PC-0COZL2, NSC-3838, AG-H-54443, ACMC-209qqg, ...
 
 
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Disease relevance of NSC 3838

  • In general, complexes that hydrolyze either rapidly {e.g., X = halide [arene = hexamethylbenzene (hmb)]} or moderately slowly [e.g., X = azide, dichloropyridine (arene = hmb)] are active toward A2780 human ovarian cancer cells, whereas complexes that do not aquate (e.g., X = py) are inactive [1].
 

Analytical, diagnostic and therapeutic context of NSC 3838

  • The low-temperature structure of hexamethylbenzene has been determined from neutron powder diffraction data and found to differ from the room-temperature phase predominantly by a translation of molecular planes to a form a cubic close-packed type structure [2].

References

  1. Controlling ligand substitution reactions of organometallic complexes: tuning cancer cell cytotoxicity. Wang, F., Habtemariam, A., van der Geer, E.P., Fernández, R., Melchart, M., Deeth, R.J., Aird, R., Guichard, S., Fabbiani, F.P., Lozano-Casal, P., Oswald, I.D., Jodrell, D.I., Parsons, S., Sadler, P.J. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  2. Determination of the low-temperature structure of hexamethylbenzene. Stride, J.A. Acta Crystallogr., B (2005) [Pubmed]
 
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