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Chemical Compound Review: 

Vargatef     methyl (3Z)-3-[[[4-[methyl-[2-(4...

Synonyms: QCR-43, cc-88, PubChem20543, S1010_Selleck, BIBF1120, ...
 
 
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Associations of Vargatef with other chemical compounds

  • The MTD of BIBF 1120 in combination with standard-dose pemetrexed was 200 mg bid [1].
  • A flow cytometric analysis revealed that BIBF 1120 significantly decreased the phosphotyrosine (pTyr) levels of VEGFR2(+)CD45(dim) PBLs and the percentage of VEGFR2(+)pTyr(+) PBLs in vivo; the latter parameter seemed to be a more feasible pharmacodynamic biomarker [2].

References

  1. Phase I open-label study of continuous treatment with BIBF 1120, a triple angiokinase inhibitor, and pemetrexed in pretreated non-small cell lung cancer patients. Ellis, P.M., Kaiser, R., Zhao, Y., Stopfer, P., Gyorffy, S., Hanna, N. Clin. Cancer Res. (2010) [Pubmed]
  2. Antitumor activity of BIBF 1120, a triple angiokinase inhibitor, and use of VEGFR2+pTyr+ peripheral blood leukocytes as a pharmacodynamic biomarker in vivo. Kudo, K., Arao, T., Tanaka, K., Nagai, T., Furuta, K., Sakai, K., Kaneda, H., Matsumoto, K., Tamura, D., Aomatsu, K., De Velasco, M.A., Fujita, Y., Saijo, N., Kudo, M., Nishio, K. Clin. Cancer Res. (2011) [Pubmed]
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