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Gene Review

ERN2  -  endoplasmic reticulum to nucleus signaling 2

Homo sapiens

Synonyms: Endoplasmic reticulum-to-nucleus signaling 2, IRE1-BETA, IRE1b, IRE2, Inositol-requiring protein 2, ...
 
 
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High impact information on ERN2

 

Biological context of ERN2

  • The fast type (IRE1) (relative mobility 1.05) had a heterozygote frequency of 1/3,780, and the slow type (IRE2) (relative mobility of 0.94) had a heterozygote frequency of 1/8,500 [2].

References

  1. The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response. Tirasophon, W., Lee, K., Callaghan, B., Welihinda, A., Kaufman, R.J. Genes Dev. (2000) [Pubmed]
  2. Purification and structural study of two albumin variants in an Irish population. Sakamoto, Y., Davis, E., Madison, J., Watkins, S., McLaughlin, H., Leahy, D.T., Putnam, F.W. Clin. Chim. Acta (1991) [Pubmed]
 
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