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Gene Review

GCN1L1  -  GCN1 general control of amino-acid...

Homo sapiens

Synonyms: GCN1, GCN1-like protein 1, GCN1L, HsGCN1, KIAA0219, ...
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High impact information on GCN1L1

  • These mutations also bypass the requirement for ribosome binding, dimerization, and association with the GCN1/GCN20 regulatory complex, suggesting that all of these functions facilitate tRNA binding to wild-type GCN2 [1].


  1. Mutations that bypass tRNA binding activate the intrinsically defective kinase domain in GCN2. Qiu, H., Hu, C., Dong, J., Hinnebusch, A.G. Genes Dev. (2002) [Pubmed]
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