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Gene Review

Tria1  -  T cell receptor induced activation 1

Mus musculus

 
 

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Disease relevance

T lymphocytes with their multiple regulatory and effector functions are one of the cornestones of vertebrate immune systems. They participate in localization and removal of virally infected and neoplastic cells, collaborate in stimulating antibody production and macrophage information. Understanding genetic regulation of their functions by loci such as Tria1 is therefore of great importance.

 

 

High impact information on Tria1

Locus Tria1 (T cell receptor induced activation 1) that controls proliferation of T lymphocytes stimulated by antiCD3 was mapped on chromosome 11 near to the marker D11Nds9 [1].

 

 

References

  1. Genetic control of T-cell proliferative response in mice linked to chromosomes 11 and 15. Havelková, H., Krulová, M., Kosarová, M., Holán, V., Hart, A.A., Demant, P., Lipoldová, M. Immunogenetics. (1996) [Pubmed]
 
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