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Gene Review

blcC  -  Zn-dependent gamma butyryl lactone lactonase

Agrobacterium fabrum str. C58

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Disease relevance of attM

  • Agrobacterium tumefaciens C58 communicates using N-acyl-homoserine lactones (acyl-HSL) and contains two lactonase-encoding genes, attM and aiiB, the products of which are capable of inactivating the acyl-HSL signal [1].

High impact information on attM

  • First, we located attJ, which codes for an IclR-type suppressor that regulates the second gene attM [2].


  1. The assimilation of gamma-butyrolactone in Agrobacterium tumefaciens C58 interferes with the accumulation of the N-acyl-homoserine lactone signal. Carlier, A., Chevrot, R., Dessaux, Y., Faure, D. Mol. Plant Microbe Interact. (2004) [Pubmed]
  2. Genetic control of quorum-sensing signal turnover in Agrobacterium tumefaciens. Zhang, H.B., Wang, L.H., Zhang, L.H. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
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