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Gene Review

fixN1  -  cbb3-type cytochrome c oxidase subunit I

Sinorhizobium meliloti 1021

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Disease relevance of fixN1

  • This is supported experimentally by showing that Fnr can substitute for FixK in activating the fixN gene in E. coli [1].
  • A 1.9 kb DNA region of Rhizobium leguminosarum biovar viciae strain VF39 capable of promoting microaerobic and symbiotic induction of the Rhizobium meliloti fixN gene was identified by heterologous complementation [2].


  1. Model-building of Fnr and FixK DNA-binding domains suggests a basis for specific DNA recognition. Cherfils, J., Gibrat, J.F., Levin, J., Batut, J., Kahn, D. J. Mol. Recognit. (1989) [Pubmed]
  2. An Fnr-like protein encoded in Rhizobium leguminosarum biovar viciae shows structural and functional homology to Rhizobium meliloti FixK. Colonna-Romano, S., Arnold, W., Schlüter, A., Boistard, P., Pühler, A., Priefer, U.B. Mol. Gen. Genet. (1990) [Pubmed]
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