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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Ccne2  -  cyclin E2

Mus musculus

Synonyms: G1/S-specific cyclin-E2
 
 
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High impact information on Ccne2

  • Elevated cyclin D1 was associated with both HK1.ras/ERK- and Delta5PTEN-mediated AKT signaling, whereas cyclin E2 overexpression seemed dependent on PTEN loss [1].
  • Furthermore, carcinogenicity study using N-nitrosomethylbenzylamine demonstrated that, compared to wild-type mice, fore-stomach tumors in E2F-1-deficient mice expressed an increased amount of cyclin E2, but not cyclin E1 [2].
 

Other interactions of Ccne2

  • Immunoblot study of E2F target genes showed that multiple passages of E2F-1-deficient cells resulted in preferential increase of cyclin E2 expression [2].

References

  1. PTEN loss promotes rasHa-mediated papillomatogenesis via dual up-regulation of AKT activity and cell cycle deregulation but malignant conversion proceeds via PTEN-associated pathways. Yao, D., Alexander, C.L., Quinn, J.A., Porter, M.J., Wu, H., Greenhalgh, D.A. Cancer Res. (2006) [Pubmed]
  2. Differential roles of E-type cyclins during transformation of murine E2F-1-deficient cells. Ishii, H., Mimori, K., Yoshikawa, Y., Mori, M., Furukawa, Y., Vecchione, A. DNA Cell Biol. (2005) [Pubmed]
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