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Gene Review

SREK1  -  splicing regulatory glutamine/lysine-rich...

Homo sapiens

Synonyms: DKFZp564B176, SFRS12, SRRP86, SRrp508, SRrp86, ...
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High impact information on SFRS12

  • Regulation of alternative splicing by SRrp86 and its interacting proteins [1].
  • Overall, we conclude that not only does SRrp86 regulate SR protein activity but that it is, in turn, regulated by other splicing factors to control alternative splice site selection [1].

Biological context of SFRS12

  • Previously, we showed that SRrp86 could regulate alternative splicing by both positively and negatively modulating the activity of other SR proteins as long as the entire region encompassing the RS-EK-RS domains was intact [2].

Analytical, diagnostic and therapeutic context of SFRS12

  • To identify the specific proteins that interact with SRrp86, we used a yeast two-hybrid library screen and immunoprecipitation coupled to mass spectrometry [1].


  1. Regulation of alternative splicing by SRrp86 and its interacting proteins. Li, J., Hawkins, I.C., Harvey, C.D., Jennings, J.L., Link, A.J., Patton, J.G. Mol. Cell. Biol. (2003) [Pubmed]
  2. A unique glutamic acid-lysine (EK) domain acts as a splicing inhibitor. Li, J., Barnard, D.C., Patton, J.G. J. Biol. Chem. (2002) [Pubmed]
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