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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Irx2  -  Iroquois related homeobox 2 (Drosophila)

Mus musculus

Synonyms: Homeodomain protein IRXA2, IRX6, Iroquois homeobox protein 2, Iroquois-class homeobox protein Irx6, Iroquois-class homeodomain protein IRX-2, ...
 
 
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High impact information on Irx2

  • The Iroquois homeobox gene Irx2 is not essential for normal development of the heart and midbrain-hindbrain boundary in mice [1].
  • Functional compensation by other Irx genes might account for the absence of a phenotype in Irx2-deficient mice [1].
  • Irx1 and Irx2 were found to be expressed specifically in the ventricular septum from the onset of its formation onward [2].
  • We report here the cloning and expression analysis of two novel mouse Irx genes, Irx5 and Irx6 [3].
 

Other interactions of Irx2

  • Expression pattern of Irx1 and Irx2 during mouse digit development [4].

References

  1. The Iroquois homeobox gene Irx2 is not essential for normal development of the heart and midbrain-hindbrain boundary in mice. Lebel, M., Agarwal, P., Cheng, C.W., Kabir, M.G., Chan, T.Y., Thanabalasingham, V., Zhang, X., Cohen, D.R., Husain, M., Cheng, S.H., Bruneau, B.G., Hui, C.C. Mol. Cell. Biol. (2003) [Pubmed]
  2. Patterning the embryonic heart: identification of five mouse Iroquois homeobox genes in the developing heart. Christoffels, V.M., Keijser, A.G., Houweling, A.C., Clout, D.E., Moorman, A.F. Dev. Biol. (2000) [Pubmed]
  3. Expression of two novel mouse Iroquois homeobox genes during neurogenesis. Cohen, D.R., Cheng, C.W., Cheng, S.H., Hui, C.C. Mech. Dev. (2000) [Pubmed]
  4. Expression pattern of Irx1 and Irx2 during mouse digit development. Zülch, A., Becker, M.B., Gruss, P. Mech. Dev. (2001) [Pubmed]
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