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Gene Review

SPRR4  -  small proline-rich protein 4

Homo sapiens

Synonyms: Small proline-rich protein 4
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High impact information on SPRR4

  • The calcium-dependent translocation of an SPRR4-GFP fusion protein to the cell periphery in living keratinocytes and its integration into both rigid and fragile cornified envelopes proved that SPRR4 is a novel CE precursor [1].
  • SPRR 4, loricrin, and LEP 6 transcripts were not detected [2].


  1. SPRR4, a novel cornified envelope precursor: UV-dependent epidermal expression and selective incorporation into fragile envelopes. Cabral, A., Sayin, A., de Winter, S., Fischer, D.F., Pavel, S., Backendorf, C. J. Cell. Sci. (2001) [Pubmed]
  2. Expression and regulation of cornified envelope proteins in human corneal epithelium. Tong, L., Corrales, R.M., Chen, Z., Villarreal, A.L., De Paiva, C.S., Beuerman, R., Li, D.Q., Pflugfelder, S.C. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
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