Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

TTC9 - tetratricopeptide repeat domain 9

Homo sapiens

Synonyms: KIAA0227, TPR repeat protein 9A, TTC9A, Tetratricopeptide repeat protein 9A

Cao, S. et al.

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Disease relevance of TTC9

Tetratricopeptide repeat domain 9 (TTC9) mRNA was drastically up-regulated by progesterone in progesterone receptor-transfected breast cancer cells MDA-MB-231 [1].

High impact information on TTC9

The level of TTC9 protein in MCF-7 cells is regulated by various factors and chemical reagents including estrogen, progesterone, growth factors, ICI182,780, and p38 kinase inhibitor SB203580 [1].
Growth factor-induced TTC9 protein expression was inhibited by estrogen and abolished by ERK inhibitor PD98059 [1].
Immunostaining and cell fractionation studies revealed that TTC9 is predominantly localized to the endoplasmic reticulum [1].

References

Identification of tetratricopeptide repeat domain 9, a hormonally regulated protein. Cao, S., Iyer, J.K., Lin, V. Biochem. Biophys. Res. Commun. (2006) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

TTC9	Bos taurus
TTC9	Canis lupus familiaris
ttc9	Danio rerio
TTC9	Gallus gallus
LOC693495	Macaca mulatta
Ttc9	Mus musculus
TTC9	Pan troglodytes
Ttc9	Rattus norvegicus
ttc9	Xenopus (Silurana) tropicalis

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