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Gene Review

PSD4  -  pleckstrin and Sec7 domain containing 4

Homo sapiens

Synonyms: EFA6B, Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B, Exchange factor for ARF6 B, PH and SEC7 domain-containing protein 4, Pleckstrin homology and SEC7 domain-containing protein 4, ...
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High impact information on PSD4

  • Like EFA6, which will be referred to as EFA6A from now on, EFA6B is involved in membrane recycling and colocalizes with ARF6 in actin-rich membrane ruffles and microvilli-like protrusions on the dorsal cell surface in transfected baby hamster kidney cells [1].

Associations of PSD4 with chemical compounds

  • We show that EFA6B, which contains a Sec7 domain that is highly homologous to EFA6, works as an ARF6-specific guanine exchange factor in vitro [1].


  1. A conserved C-terminal domain of EFA6-family ARF6-guanine nucleotide exchange factors induces lengthening of microvilli-like membrane protrusions. Derrien, V., Couillault, C., Franco, M., Martineau, S., Montcourrier, P., Houlgatte, R., Chavrier, P. J. Cell. Sci. (2002) [Pubmed]
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