The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Lrrc4c  -  leucine rich repeat containing 4C

Mus musculus

Synonyms: 6430556C10Rik, Leucine-rich repeat-containing protein 4C, NGL-1, Netrin-G1 ligand, Ngl1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Lrrc4c

  • Natural glycolipids (NGL-1 and -2) which were prepared from a chloroform-methanol extract of Streptococcus pyogenes and E. hirae cells, and comparable in structure to the lipid moieties of the LTA-1 and -2 fractions, respectively, were practically inactive in all of the assays [1].

High impact information on Lrrc4c

  • Finally, we show that the transmembrane netrin-G1 ligand (NGL-1) binds to the PDZ1 and PDZ2 domains of whirlin and has an extracellular region that homophilically self-interacts in a Ca2+-dependent manner [2].

Other interactions of Lrrc4c

  • The interaction between whirlin and NGL-1 might be involved in the stabilization of interstereociliar links [2].


  1. Molecular and structural requirements of a lipoteichoic acid from Enterococcus hirae ATCC 9790 for cytokine-inducing, antitumor, and antigenic activities. Takada, H., Kawabata, Y., Arakaki, R., Kusumoto, S., Fukase, K., Suda, Y., Yoshimura, T., Kokeguchi, S., Kato, K., Komuro, T. Infect. Immun. (1995) [Pubmed]
  2. Myosin XVa and whirlin, two deafness gene products required for hair bundle growth, are located at the stereocilia tips and interact directly. Delprat, B., Michel, V., Goodyear, R., Yamasaki, Y., Michalski, N., El-Amraoui, A., Perfettini, I., Legrain, P., Richardson, G., Hardelin, J.P., Petit, C. Hum. Mol. Genet. (2005) [Pubmed]
WikiGenes - Universities