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High impact information on FRA11G
- Here, we show that FRA11G maps 0.8 Mb proximal to the genomic region previously defined to be affected by expression of FRA11B; thus, the common and the rare fragile sites at 11q23.3 encompass distinct genomic regions [1].
- In this study, cloning of unstable DNA sequences, which have been previously genetically tagged with a marker gene, was the basis for defining the genomic localization of the common fragile site FRA11G at 11q23 [1].
- The region of FRA11G is known to be involved in somatic and germline recurrent aberrations, and it is conceivable that genetic damage resulting from this fragile site might contribute to clinical phenotypes [1].
Analytical, diagnostic and therapeutic context of FRA11G
- 3. Mapping of the fragile site with six-color fluorescence in situ hybridization (FISH) resulted in the precise genomic localization of FRA11G to a 4.5 Mb region [1].
References
- Common fragile site FRA11G and rare fragile site FRA11B at 11q23.3 encompass distinct genomic regions. Fechter, A., Buettel, I., Kuehnel, E., Savelyeva, L., Schwab, M. Genes Chromosomes Cancer (2007) [Pubmed]
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