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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Table of contents

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Gene Review: 

Phex  -  phosphate regulating endopeptidase homolog...

Rattus norvegicus

 
 

 

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Disease relevance of Phex

 

High impact information on Phex

  • IGF-I and GH stimulate Phex mRNA expression in lungs and bones and 1,25-dihydroxyvitamin D(3) production in hypophysectomized rats [2].
  • The mineralization-inhibiting protein osteopontin [3] abundant in the extracellular matrix of bone, and in tooth dentin and cementum, is a substrate for PHEX [4] [5]; PHEX essentially completely degrades inhibitory OPN [4].
 

Other interactions of Phex

  • CONCLUSIONS: Our findings suggest a coordinate regulation of Phex mRNA expression in lungs and bone and vitamin D metabolism during GH- and IGF-I-stimulated growth [2].

References

  1. Dietary phosphorus deprivation induces 25-hydroxyvitamin D(3) 1alpha-hydroxylase gene expression. Yoshida, T., Yoshida, N., Monkawa, T., Hayashi, M., Saruta, T. Endocrinology (2001) [Pubmed]
  2. IGF-I and GH stimulate Phex mRNA expression in lungs and bones and 1,25-dihydroxyvitamin D(3) production in hypophysectomized rats. Zoidis, E., Gosteli-Peter, M., Ghirlanda-Keller, C., Meinel, L., Zapf, J., Schmid, C. Eur. J. Endocrinol. (2002) [Pubmed]
  3. Osteopontin. Sodek, J., Ganss, B., McKee, M.D. Crit. Rev. Oral. Biol. Med. (2000) [Pubmed]
  4. Proteolytic processing of osteopontin by PHEX and accumulation of osteopontin fragments in Hyp mouse bone, the murine model of X-linked hypophosphatemia. Barros, N.M., Hoac, B., Neves, R.L., Addison, W.N., Assis, D.M., Murshed, M., Carmona, A.K., McKee, M.D. J. Bone. Miner. Res. (2013) [Pubmed]
  5. Extracellular matrix mineralization in periodontal tissues: Noncollagenous matrix proteins, enzymes, and relationship to hypophosphatasia and X-linked hypophosphatemia. McKee, M.D., Hoac, B., Addison, W.N., Barros, N.M., Millán, J.L., Chaussain, C. Periodontol. 2000. (2013) [Pubmed]
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