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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Gene Expression

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Disease relevance of Gene Expression


Psychiatry related information on Gene Expression


High impact information on Gene Expression

  • Although chemically unrelated, CsA and FK-506 affect a similar subset of calcium-associated signaling events involved in the regulation of lymphokine gene expression, activation-driven T-cell death and exocytosis [11].
  • Presentation of immunoregulatory signals to transformed B cells can profoundly influence their proliferation, morphology, differentiation, gene expression, and immunoglobulin synthesis [12].
  • Through these regulatory mechanisms, IP3R modulates diverse cellular functions, which include, but are not limited to, contraction/excitation, secretion, gene expression, and cellular growth [13].
  • Below we describe these recent advances, which highlight the important role of the RNA polymerase II elongation complex in regulation of eukaryotic gene expression [14].
  • We further examine the evidence for independent signaling by PGHS-1 and PGHS-2, and the complex mechanisms for regulation of PGHS-2 gene expression [15].

Chemical compound and disease context of Gene Expression


Biological context of Gene Expression


Anatomical context of Gene Expression


Associations of Gene Expression with chemical compounds


Gene context of Gene Expression

  • These proteins also activate MAP kinase (MAPK) cascades that regulate gene expression [36].
  • Whereas some p38alpha(-/-) embryos die between embryonic days 11.5 and 12.5, those that develop past this stage have normal morphology but are anemic owing to failed definitive erythropoiesis, caused by diminished erythropoietin (Epo) gene expression [37].
  • Levels of MRP gene expression were significantly higher in tumors with N-myc amplification than in tumors without such amplification (P < 0.001) [3].
  • Spatial regulation of Antennapedia and bithorax gene expression by the Polycomb locus in Drosophila [38].
  • RESULTS: Permutation analysis of multivariate classification functions established that the gene-expression profiles of tumors with BRCA1 mutations, tumors with BRCA2 mutations, and sporadic tumors differed significantly from each other [39].

Analytical, diagnostic and therapeutic context of Gene Expression


  1. Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1. Carroll, J.S., Liu, X.S., Brodsky, A.S., Li, W., Meyer, C.A., Szary, A.J., Eeckhoute, J., Shao, W., Hestermann, E.V., Geistlinger, T.R., Fox, E.A., Silver, P.A., Brown, M. Cell (2005) [Pubmed]
  2. Stochastic gene expression in a lentiviral positive-feedback loop: HIV-1 Tat fluctuations drive phenotypic diversity. Weinberger, L.S., Burnett, J.C., Toettcher, J.E., Arkin, A.P., Schaffer, D.V. Cell (2005) [Pubmed]
  3. Expression of the gene for multidrug-resistance-associated protein and outcome in patients with neuroblastoma. Norris, M.D., Bordow, S.B., Marshall, G.M., Haber, P.S., Cohn, S.L., Haber, M. N. Engl. J. Med. (1996) [Pubmed]
  4. Bacillus subtilis glutamine synthetase controls gene expression through a protein-protein interaction with transcription factor TnrA. Wray, L.V., Zalieckas, J.M., Fisher, S.H. Cell (2001) [Pubmed]
  5. Wilms' tumor 1 and Dax-1 modulate the orphan nuclear receptor SF-1 in sex-specific gene expression. Nachtigal, M.W., Hirokawa, Y., Enyeart-VanHouten, D.L., Flanagan, J.N., Hammer, G.D., Ingraham, H.A. Cell (1998) [Pubmed]
  6. CLOCK, an essential pacemaker component, controls expression of the circadian transcription factor DBP. Ripperger, J.A., Shearman, L.P., Reppert, S.M., Schibler, U. Genes Dev. (2000) [Pubmed]
  7. B-cell factor 1 is required for optimal expression of the DRA promoter in B cells. Voliva, C.F., Aronheim, A., Walker, M.D., Peterlin, B.M. Mol. Cell. Biol. (1992) [Pubmed]
  8. Dopamine D1 and D2 receptor gene expression in the striatum in Huntington's disease. Augood, S.J., Faull, R.L., Emson, P.C. Ann. Neurol. (1997) [Pubmed]
  9. Dysregulation of diurnal rhythms of serotonin 5-HT2C and corticosteroid receptor gene expression in the hippocampus with food restriction and glucocorticoids. Holmes, M.C., French, K.L., Seckl, J.R. J. Neurosci. (1997) [Pubmed]
  10. Aberrant GAP-43 gene expression in Alzheimer's disease. de la Monte, S.M., Ng, S.C., Hsu, D.W. Am. J. Pathol. (1995) [Pubmed]
  11. Cyclosporin A, FK-506, and rapamycin: pharmacologic probes of lymphocyte signal transduction. Sigal, N.H., Dumont, F.J. Annu. Rev. Immunol. (1992) [Pubmed]
  12. The physiology of B cells as studied with tumor models. Hanley-Hyde, J.M., Lynch, R.G. Annu. Rev. Immunol. (1986) [Pubmed]
  13. Inositol 1,4,5-trisphosphate receptors as signal integrators. Patterson, R.L., Boehning, D., Snyder, S.H. Annu. Rev. Biochem. (2004) [Pubmed]
  14. The RNA polymerase II elongation complex. Shilatifard, A., Conaway, R.C., Conaway, J.W. Annu. Rev. Biochem. (2003) [Pubmed]
  15. Cyclooxygenases: structural, cellular, and molecular biology. Smith, W.L., DeWitt, D.L., Garavito, R.M. Annu. Rev. Biochem. (2000) [Pubmed]
  16. Retinoic acid and thyroid hormone induce gene expression through a common responsive element. Umesono, K., Giguere, V., Glass, C.K., Rosenfeld, M.G., Evans, R.M. Nature (1988) [Pubmed]
  17. Adipsin and complement factor D activity: an immune-related defect in obesity. Rosen, B.S., Cook, K.S., Yaglom, J., Groves, D.L., Volanakis, J.E., Damm, D., White, T., Spiegelman, B.M. Science (1989) [Pubmed]
  18. A DNA binding protein regulated by IL-4 and by differentiation in B cells. Boothby, M., Gravallese, E., Liou, H.C., Glimcher, L.H. Science (1988) [Pubmed]
  19. Compensatory ahpC gene expression in isoniazid-resistant Mycobacterium tuberculosis. Sherman, D.R., Mdluli, K., Hickey, M.J., Arain, T.M., Morris, S.L., Barry, C.E., Stover, C.K. Science (1996) [Pubmed]
  20. Crystal structure of DCoH, a bifunctional, protein-binding transcriptional coactivator. Endrizzi, J.A., Cronk, J.D., Wang, W., Crabtree, G.R., Alber, T. Science (1995) [Pubmed]
  21. Cellular and molecular neuroscience of alcoholism. Diamond, I., Gordon, A.S. Physiol. Rev. (1997) [Pubmed]
  22. Nuclear hormone receptors and gene expression. Aranda, A., Pascual, A. Physiol. Rev. (2001) [Pubmed]
  23. Gene regulation by histone H1: new links to DNA methylation. Rupp, R.A., Becker, P.B. Cell (2005) [Pubmed]
  24. A novel transcription factor reveals a functional link between the RNA polymerase II CTD and TFIID. Koleske, A.J., Buratowski, S., Nonet, M., Young, R.A. Cell (1992) [Pubmed]
  25. CREB phosphorylation and dephosphorylation: a Ca(2+)- and stimulus duration-dependent switch for hippocampal gene expression. Bito, H., Deisseroth, K., Tsien, R.W. Cell (1996) [Pubmed]
  26. Human surfactant protein B: structure, function, regulation, and genetic disease. Whitsett, J.A., Nogee, L.M., Weaver, T.E., Horowitz, A.D. Physiol. Rev. (1995) [Pubmed]
  27. Transcriptional control of osteoblast growth and differentiation. Stein, G.S., Lian, J.B., Stein, J.L., Van Wijnen, A.J., Montecino, M. Physiol. Rev. (1996) [Pubmed]
  28. Acetylcholine receptor gene expression at the developing neuromuscular junction. Duclert, A., Changeux, J.P. Physiol. Rev. (1995) [Pubmed]
  29. branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and the pattern of branching. Sutherland, D., Samakovlis, C., Krasnow, M.A. Cell (1996) [Pubmed]
  30. Mvwf, a dominant modifier of murine von Willebrand factor, results from altered lineage-specific expression of a glycosyltransferase. Mohlke, K.L., Purkayastha, A.A., Westrick, R.J., Smith, P.L., Petryniak, B., Lowe, J.B., Ginsburg, D. Cell (1999) [Pubmed]
  31. Regulation of phosphoenolpyruvate carboxykinase (GTP) gene expression. Hanson, R.W., Reshef, L. Annu. Rev. Biochem. (1997) [Pubmed]
  32. Transcriptional regulation by cyclic AMP. Montminy, M. Annu. Rev. Biochem. (1997) [Pubmed]
  33. Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2. Guillam, M.T., Hümmler, E., Schaerer, E., Yeh, J.I., Birnbaum, M.J., Beermann, F., Schmidt, A., Dériaz, N., Thorens, B., Wu, J.Y. Nat. Genet. (1997) [Pubmed]
  34. The thyroid hormone receptor binds with opposite transcriptional effects to a common sequence motif in thyroid hormone and estrogen response elements. Glass, C.K., Holloway, J.M., Devary, O.V., Rosenfeld, M.G. Cell (1988) [Pubmed]
  35. Control of globin gene expression by steroid hormones in differentiating Friend leukemia cells. Lo, S.C., Aft, R., Ross, J., Mueller, G.C. Cell (1978) [Pubmed]
  36. Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Minden, A., Lin, A., Claret, F.X., Abo, A., Karin, M. Cell (1995) [Pubmed]
  37. Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. Tamura, K., Sudo, T., Senftleben, U., Dadak, A.M., Johnson, R., Karin, M. Cell (2000) [Pubmed]
  38. Spatial regulation of Antennapedia and bithorax gene expression by the Polycomb locus in Drosophila. Wedeen, C., Harding, K., Levine, M. Cell (1986) [Pubmed]
  39. Gene-expression profiles in hereditary breast cancer. Hedenfalk, I., Duggan, D., Chen, Y., Radmacher, M., Bittner, M., Simon, R., Meltzer, P., Gusterson, B., Esteller, M., Kallioniemi, O.P., Wilfond, B., Borg, A., Trent, J. N. Engl. J. Med. (2001) [Pubmed]
  40. Lamr1 functional retroposon causes right ventricular dysplasia in mice. Asano, Y., Takashima, S., Asakura, M., Shintani, Y., Liao, Y., Minamino, T., Asanuma, H., Sanada, S., Kim, J., Ogai, A., Fukushima, T., Oikawa, Y., Okazaki, Y., Kaneda, Y., Sato, M., Miyazaki, J., Kitamura, S., Tomoike, H., Kitakaze, M., Hori, M. Nat. Genet. (2004) [Pubmed]
  41. Deficiency in short-chain fatty acid beta-oxidation affects theta oscillations during sleep. Tafti, M., Petit, B., Chollet, D., Neidhart, E., de Bilbao, F., Kiss, J.Z., Wood, P.A., Franken, P. Nat. Genet. (2003) [Pubmed]
  42. Prolactin-mediated transcriptional and post-transcriptional control of casein gene expression. Guyette, W.A., Matusik, R.J., Rosen, J.M. Cell (1979) [Pubmed]
  43. A polymorphism that affects OCT-1 binding to the TNF promoter region is associated with severe malaria. Knight, J.C., Udalova, I., Hill, A.V., Greenwood, B.M., Peshu, N., Marsh, K., Kwiatkowski, D. Nat. Genet. (1999) [Pubmed]
  44. Human CCAAT displacement protein is homologous to the Drosophila homeoprotein, cut. Neufeld, E.J., Skalnik, D.G., Lievens, P.M., Orkin, S.H. Nat. Genet. (1992) [Pubmed]
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