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Gene Review

RNF144B  -  ring finger protein 144B

Homo sapiens

Synonyms: E3 ubiquitin-protein ligase RNF144B, IBR domain-containing protein 2, IBRDC2, P53RFP, PIR2, ...
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High impact information on IBRDC2

  • Our results further suggest that p53 might regulate the stability of p21(WAF1) through transcriptional regulation of p53RFP, and this feature may represent a novel mechanism for a p53-dependent cell-cycle checkpoint [1].
  • The p53-inducible E3 ubiquitin ligase p53RFP induces p53-dependent apoptosis [2].

Other interactions of IBRDC2


  1. p53RFP, a p53-inducible RING-finger protein, regulates the stability of p21WAF1. Ng, C.C., Arakawa, H., Fukuda, S., Kondoh, H., Nakamura, Y. Oncogene (2003) [Pubmed]
  2. The p53-inducible E3 ubiquitin ligase p53RFP induces p53-dependent apoptosis. Huang, J., Xu, L.G., Liu, T., Zhai, Z., Shu, H.B. FEBS Lett. (2006) [Pubmed]
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