Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

RNF144B - ring finger protein 144B

Homo sapiens

Synonyms: E3 ubiquitin-protein ligase RNF144B, IBR domain-containing protein 2, IBRDC2, P53RFP, PIR2, ...

Ng, C.C. et al., Huang, J. et al.

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High impact information on IBRDC2

Our results further suggest that p53 might regulate the stability of p21(WAF1) through transcriptional regulation of p53RFP, and this feature may represent a novel mechanism for a p53-dependent cell-cycle checkpoint [1].
The p53-inducible E3 ubiquitin ligase p53RFP induces p53-dependent apoptosis [2].

Other interactions of IBRDC2

Here we report the isolation of a novel transcriptional target of p53, designated p53RFP (p53-inducible RING-finger protein), whose product has E3 ubiquitin ligase activity [1].

References

p53RFP, a p53-inducible RING-finger protein, regulates the stability of p21WAF1. Ng, C.C., Arakawa, H., Fukuda, S., Kondoh, H., Nakamura, Y. Oncogene (2003) [Pubmed]
The p53-inducible E3 ubiquitin ligase p53RFP induces p53-dependent apoptosis. Huang, J., Xu, L.G., Liu, T., Zhai, Z., Shu, H.B. FEBS Lett. (2006) [Pubmed]

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zgc:63907	Danio rerio
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