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Gene Review

tcfA  -  tracheal colonization factor

Bordetella pertussis Tohama I

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Disease relevance of tcfA

  • The UK isolates were assigned multi-locus sequence types (MLSTs) according to a previously described scheme for B. pertussis based on three of these genes (ptxA, ptxC and tcfA) [1].

High impact information on tcfA

  • In modern isolates, polymorphism was observed only in prn, ptxS1, ptxS3, and tcfA [2].


  1. Sequence variation and conservation in virulence-related genes of Bordetella pertussis isolates from the UK. Packard, E.R., Parton, R., Coote, J.G., Fry, N.K. J. Med. Microbiol. (2004) [Pubmed]
  2. Multilocus sequence typing of Bordetella pertussis based on surface protein genes. van Loo, I.H., Heuvelman, K.J., King, A.J., Mooi, F.R. J. Clin. Microbiol. (2002) [Pubmed]
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