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Gene Review: 

ADRA2A  -  adrenoceptor alpha 2A

Bos taurus

 
 
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Disease relevance of ADRA2A

 

High impact information on ADRA2A

  • This study demonstrates that the alpha 2AAR incorporates [3H] palmitic acid in metabolic labeling studies and that mutation of Cys-442 to Ala or Ser eliminates detectable 3H-palmitoylation [1].
  • Like most members of the G-protein-coupled receptor superfamily, the primary structure of the alpha 2AAR possesses a putative consensus sequence for palmitoylation in the COOH terminus at Cys-442 [1].
  • This report describes cloning of the bovine alpha 2D-adrenergic receptor (alpha 2D-AR) gene and determination of the transcription start site, unequivocal presence of the alpha 2D-AR transcript in the retina, and pharmacological characteristics of the encoded product [2].

References

  1. Mutations of the alpha 2A-adrenergic receptor that eliminate detectable palmitoylation do not perturb receptor-G-protein coupling. Kennedy, M.E., Limbird, L.E. J. Biol. Chem. (1993) [Pubmed]
  2. The bovine alpha 2D-adrenergic receptor gene: structure, expression in retina, and pharmacological characterization of the encoded receptor. Venkataraman, V., Duda, T., Sharma, R.K. Mol. Cell. Biochem. (1997) [Pubmed]
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