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Gene Review:

IGHV3-21 - immunoglobulin heavy variable 3-21

Homo sapiens

Synonyms: IGHV321, VH

Ghia, P. et al.

Ghia, Stamatopoulos, Belessi, Moreno, Stella, Guida, Michel, Crespo, Laoutaris, Montserrat, Anagnostopoulos, Dighiero, Fassas, Caligaris-Cappio, Davi,

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Disease relevance of IGHV3-21

Geographic patterns and pathogenetic implications of IGHV gene usage in chronic lymphocytic leukemia: the lesson of the IGHV3-21 gene [1].

High impact information on IGHV3-21

The first one (7 of 16 cases) carried a similar HCDR3 amino acid sequence (common-HCDR3 subset), virtually identical to the Scandinavian IGHV3-21 CLL [1].

References

Geographic patterns and pathogenetic implications of IGHV gene usage in chronic lymphocytic leukemia: the lesson of the IGHV3-21 gene. Ghia, P., Stamatopoulos, K., Belessi, C., Moreno, C., Stella, S., Guida, G., Michel, A., Crespo, M., Laoutaris, N., Montserrat, E., Anagnostopoulos, A., Dighiero, G., Fassas, A., Caligaris-Cappio, F., Davi, F. Blood (2005) [Pubmed]

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