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Gene Review

RBM15B  -  RNA binding motif protein 15B

Homo sapiens

Synonyms: HUMAGCGB, HuOTT3, OTT3, One-twenty two protein 3, RNA-binding motif protein 15B
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Disease relevance of RBM15B

  • Most interestingly, however, we have found that OTT3 has a role in splicing regulation; OTT3 represses accumulation of the alternatively spliced beta-thalassemia mRNAs, but it has no effect on the beta-globin constitutively spliced mRNA [1].


  1. Interaction of the Epstein-Barr virus mRNA export factor EB2 with human Spen proteins SHARP, OTT1, and a novel member of the family, OTT3, links Spen proteins with splicing regulation and mRNA export. Hiriart, E., Gruffat, H., Buisson, M., Mikaelian, I., Keppler, S., Meresse, P., Mercher, T., Bernard, O.A., Sergeant, A., Manet, E. J. Biol. Chem. (2005) [Pubmed]
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