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Gene Review

4EHP  -  eIF4E-Homologous Protein

Drosophila melanogaster

Synonyms: 4E-HP, CG10716, CG33100, CT30033, Dmel\CG33100, ...
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High impact information on 4EHP

  • Thus, simultaneous interactions of d4EHP with the cap structure and of Bcd with BBR renders cad mRNA translationally inactive [1].
  • Thus, by regulating Cad and Hb expression, d4EHP plays a key role in establishing anterior-posterior axis polarity in the Drosophila embryo [2].


  1. A new paradigm for translational control: inhibition via 5'-3' mRNA tethering by Bicoid and the eIF4E cognate 4EHP. Cho, P.F., Poulin, F., Cho-Park, Y.A., Cho-Park, I.B., Chicoine, J.D., Lasko, P., Sonenberg, N. Cell (2005) [Pubmed]
  2. Cap-dependent translational inhibition establishes two opposing morphogen gradients in Drosophila embryos. Cho, P.F., Gamberi, C., Cho-Park, Y.A., Cho-Park, I.B., Lasko, P., Sonenberg, N. Curr. Biol. (2006) [Pubmed]
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