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Gene Review

RAB7B  -  RAB7B, member RAS oncogene family

Homo sapiens

Synonyms: MGC16212, MGC9726, Ras-related protein Rab-7b
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High impact information on RAB7B

  • Genomic RNA localization at the MTOC that was both the result of hnRNP A2 knockdown and the overexpression of Rab7-interacting lysosomal protein had little effect on pr55Gag synthesis but negatively influenced virus production and infectivity [1].
  • Here we report the cloning and characterization of a novel Rab7-like GTPase, which shares highest homology with Rab7 and thus is designated as Rab7b [2].


  1. Trafficking of HIV-1 RNA is mediated by heterogeneous nuclear ribonucleoprotein A2 expression and impacts on viral assembly. L??vesque, K., Halvorsen, M., Abrahamyan, L., Chatel-Chaix, L., Poupon, V., Gordon, H., DesGroseillers, L., Gatignol, A., Mouland, A.J. Traffic (2006) [Pubmed]
  2. Rab7b, a novel lysosome-associated small GTPase, is involved in monocytic differentiation of human acute promyelocytic leukemia cells. Yang, M., Chen, T., Han, C., Li, N., Wan, T., Cao, X. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
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