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Gene Review:

regA - cAMP phosphodiesterase

Dictyostelium discoideum AX4

Shaulsky, G. et al., Lusche, D.F. et al., Zhang, H. et al., Tekinay, T. et al., Anjard, C. et al.

Lusche, Bezares-Roder, Happle, Schlatterer,

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High impact information on regA

One of these genes, mkcA, is a member of the mitogen-activating protein kinase cascade family while the other, regA is a novel bipartite gene homologous to response regulators in one part and to cyclic nucleotide phosphodiesterases in the other part [1].
However, we found that regA- mutant cells release a distinct factor, SDF-2, that rapidly induces encapsulation of test cells overexpressing pkaC [2].
CONCLUSION: We conclude that there is a link between the second messengers cAMP and Ca2+. cAMP-dependent protein kinase (PKA) could provide for this link as a membrane-permeable PKA-activator also increased basal [Ca2+]i of regA- cells [3].
The behavioral abnormalities that pkaR mutant cells shared with regA mutant cells are discussed by considering the pathway ERK2 perpendicular RegA perpendicular [cAMP] --> PKA, which emanates from the front of a wave [4].
One suppressor mutation resides within the gene regA, which encodes a cyclic AMP (cAMP) phosphodiesterase linked to an activating response regulator domain [5].

References

Developmental signal transduction pathways uncovered by genetic suppressors. Shaulsky, G., Escalante, R., Loomis, W.F. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
Signal transduction pathways leading to spore differentiation in Dictyostelium discoideum. Anjard, C., Zeng, C., Loomis, W.F., Nellen, W. Dev. Biol. (1998) [Pubmed]
cAMP controls cytosolic Ca2+ levels in Dictyostelium discoideum. Lusche, D.F., Bezares-Roder, K., Happle, K., Schlatterer, C. BMC Cell Biol. (2005) [Pubmed]
Constitutively active protein kinase A disrupts motility and chemotaxis in Dictyostelium discoideum. Zhang, H., Heid, P.J., Wessels, D., Daniels, K.J., Pham, T., Loomis, W.F., Soll, D.R. Eukaryotic Cell (2003) [Pubmed]
Genetic interactions of the E3 ubiquitin ligase component FbxA with cyclic AMP metabolism and a histidine kinase signaling pathway during Dictyostelium discoideum development. Tekinay, T., Ennis, H.L., Wu, M.Y., Nelson, M., Kessin, R.H., Ratner, D.I. Eukaryotic Cell (2003) [Pubmed]

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