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Gene Review:

CTA_0306 - phospholipase D

Chlamydia trachomatis A/HAR-13

Nelson, D.E. et al.

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Disease relevance of CTA_0306

Here, we show that the PZ PLD (pzPLD) of Chlamydia trachomatis are transcribed during both normal and persistent infection and that the corresponding PLD proteins are predominantly localized in reticulate bodies on the inner leaflet of the inclusion membrane [1].

High impact information on CTA_0306

Comparative genomics studies have determined that an uncharacterized family of PZ genes encoding orthologs of eukaryotic and prokaryotic members of the phospholipase D (PLD) enzyme family varies among chlamydiae [1].

References

Inhibition of chlamydiae by primary alcohols correlates with the strain-specific complement of plasticity zone phospholipase D genes. Nelson, D.E., Crane, D.D., Taylor, L.D., Dorward, D.W., Goheen, M.M., Caldwell, H.D. Infect. Immun. (2006) [Pubmed]

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