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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

POSH  -  Plenty of SH3s

Drosophila melanogaster

Synonyms: 155116_at, BEST:GM09451, CG4909, DPOSH, Dmel\CG4909, ...
 
 
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High impact information on POSH

  • Neural-specific overexpression of DPOSH is sufficient to extend the longevity, whereas overexpression in non-neural tissues during development induces apoptosis through activation of JNK/SAPK pathway [1].
  • In contrast, forced expression of DPOSH in developing imaginal discs produced various phenotypes including lethality and morphological defects such as loss of crossvein, notched wing, and disordered hair polarity [2].

References

  1. Longevity determination genes in Drosophila melanogaster. Aigaki, T., Seong, K.H., Matsuo, T. Mech. Ageing Dev. (2002) [Pubmed]
  2. Neural-specific overexpression of drosophila plenty of SH3s (DPOSH) extends the longevity of adult flies. Seong, K.H., Matsuo, T., Fuyama, Y., Aigaki, T. Biogerontology. (2001) [Pubmed]
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