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Gene Review: 

Ack  -  Activated Cdc42 kinase

Drosophila melanogaster

Synonyms: ACK, ACK2, BcDNA:GH10777, CG14992, DACK, ...
 
 
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High impact information on Ack

  • We extend this powerful technique to study two proteins, DSH3PX1 and Drosophila ACK (DACK) [1].
  • We have characterized Drosophila melanogaster ACK (DACK), one of two members of the ACK family of nonreceptor tyrosine kinases in DROSOPHILA: The ACKs are likely effectors for the small GTPase Cdc42, but signaling by these proteins remains poorly defined [2].

References

  1. Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways. Clemens, J.C., Worby, C.A., Simonson-Leff, N., Muda, M., Maehama, T., Hemmings, B.A., Dixon, J.E. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  2. ACK family tyrosine kinase activity is a component of Dcdc42 signaling during dorsal closure in Drosophila melanogaster. Sem, K.P., Zahedi, B., Tan, I., Deak, M., Lim, L., Harden, N. Mol. Cell. Biol. (2002) [Pubmed]
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