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Gene Review:

adam10 - ADAM metallopeptidase domain 10

Xenopus laevis

Synonyms: ad10, cd156c, kuz, kuzbanian, madm, ...

Smith, K.M. et al.

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Disease relevance of ADAM10

When expressed in embryos, ADAM13 induces hyperplasia of the cement gland, whereas ADAM10 does not [1].

High impact information on ADAM10

Using chimeric constructs, we find that the metalloprotease domain of ADAM10 can substitute for that of ADAM13, but that specificity for cement gland expansion requires a downstream extracellular domain of ADAM13 [1].

References

The cysteine-rich domain regulates ADAM protease function in vivo. Smith, K.M., Gaultier, A., Cousin, H., Alfandari, D., White, J.M., DeSimone, D.W. J. Cell Biol. (2002) [Pubmed]

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