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Gene Review

BCAR4  -  breast cancer anti-estrogen resistance 4...

Homo sapiens

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Disease relevance of BCAR4

  • We showed that ectopic expression of this gene, designated as breast cancer antiestrogen resistance 4 (BCAR4), caused OH-TAM resistance and anchorage-independent cell growth in ZR-75-1 cells and that the intact open reading frame was required for its function [1].
  • [2]


  1. Functional screen for genes responsible for tamoxifen resistance in human breast cancer cells. Meijer, D., van Agthoven, T., Bosma, P.T., Nooter, K., Dorssers, L.C. Mol. Cancer Res. (2006) [Pubmed]
  2. Relevance of BCAR4 in tamoxifen resistance and tumour aggressiveness of human breast cancer. Godinho, M.F., Sieuwerts, A.M., Look, M.P., Meijer, D., Foekens, J.A., Dorssers, L.C., van Agthoven, T. Br. J. Cancer. (2010) [Pubmed]
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