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Gene Review

MIR184  -  microRNA 184

Homo sapiens

Synonyms: EDICT, MIRN184, hsa-mir-184, miR-184

Disease Relevance of MIRN184

  • Rett syndrome. [1]
  • Elevation of miR-184 was observed in squamous cell carcinoma of the tongue and inhibition of miR-184 reduced proliferation of tongue SCC cell lines slightly.[2]
  • all-trans-retinoic acid induces miR-184 expression in a neuroblastoma cell line and ectopic miR-184 causes apoptosis. [3]. This is mediated at least in part by miR-184-dependent reduction of AKT2 expression [4]
  • miR-184 has also been implicated in ischemia-induced retinal neovascularization. [5]



High impact information on miR-184



  • miR-184 is abundant in the corneal epithelium. [8]
  • High miR-184 expression was observed in mouse testis, with lower expression in brain tissue. [1]
  • Depolarization of cortical neurons resulted in pri-miR-184 expression in an allele-specific manner. [1]
  • The expression of miR-184 detected in umbilical cord blood-derived CD4(+) T cells was 58.4-fold higher than that observed in adult blood CD4(+) T cells. [7]

Other interactions of miR-184

  • In Drosophila S2 cells, miR-184 appeared to repress some target mRNAs by binding to specific sites in their coding regions [9].


  1. MeCP2-dependent repression of an imprinted miR-184 released by depolarization. Nomura, T., Kimura, M., Horii, T., Morita, S., Soejima, H., Kudo, S., Hatada, I. Hum. Mol. Genet. (2008) [Pubmed]
  2. Mature miR-184 as Potential Oncogenic microRNA of Squamous Cell Carcinoma of Tongue. Wong, T.S., Liu, X.B., Wong, B.Y., Ng, R.W., Yuen, A.P., Wei, W.I. Clin. Cancer. Res. (2008) [Pubmed]
  3. Differential patterns of microRNA expression in neuroblastoma are correlated with prognosis, differentiation, and apoptosis. Chen, Y., Stallings, R.L. Cancer. Res. (2007) [Pubmed]
  4. MicroRNA-184 inhibits neuroblastoma cell survival through targeting the serine/threonine kinase AKT2. Foley, N.H., Bray, I.M., Tivnan, A., Bryan, K., Murphy, D.M., Buckley, P.G., Ryan, J., O'Meara, A., O'Sullivan, M., Stallings, R.L. Mol. Cancer. (2010) [Pubmed]
  5. MicroRNAs regulate ocular neovascularization. Shen, J., Yang, X., Xie, B., Chen, Y., Swaim, M., Hackett, S.F., Campochiaro, P.A. Mol. Ther. (2008) [Pubmed]
  6. MicroRNA-184 antagonizes microRNA-205 to maintain SHIP2 levels in epithelia. Yu, J., Ryan, D.G., Getsios, S., Oliveira-Fernandes, M., Fatima, A., Lavker, R.M. Proc. Natl. Acad. Sci. U. S. A. (2008) [Pubmed]
  7. MicroRNA 184 regulates expression of NFAT1 in umbilical cord blood CD4+ T-cells. Weitzel, R.P., Lesniewski, M.L., Haviernik, P., Kadereit, S., Leahy, P., Greco, N.J., Laughlin, M.J. Blood. (2009) [Pubmed]
  8. MicroRNAs of the mammalian eye display distinct and overlapping tissue specificity. Ryan, D.G., Oliveira-Fernandes, M., Lavker, R.M. Mol. Vis. (2006) [Pubmed]
  9. Isolation of microRNA targets by miRNP immunopurification. Easow, G., Teleman, A.A., Cohen, S.M. RNA. (2007) [Pubmed]
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