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Gene Review

MIR199B  -  microRNA 199b

Homo sapiens

Synonyms: MIRN199B, hsa-mir-199b, mir-199b
 
 

Disease relevance of miR-199b

Reduced expression of miR-199b-5p appears to be associated with metastatic medullobalstoma and poor prognosis for patients [1].

Expression

Detected by quantitative PCR in the cerebellum, with higher levels of expression in infants (0-1 year-olds) compared to teenagers (13-16 year-olds) [1].

High impact information on miR-199b-5p

miR-199b-5p suppresses HES1 expression, reducing proliferation and anchorage independent growth of medulloblastoma cells

Biological context of miR-199b-5p

Six miRNAs, including miR-199b-5p, were down-regulated during differentiation of HL-60 leukemic cells by 4-hydroxynonenal, a lipid peroxidation product [2].

References

  1. MicroRNA-199b-5p impairs cancer stem cells through negative regulation of HES1 in medulloblastoma. Garzia, L., Andolfo, I., Cusanelli, E., Marino, N., Petrosino, G., De Martino, D., Esposito, V., Galeone, A., Navas, L., Esposito, S., Gargiulo, S., Fattet, S., Donofrio, V., Cinalli, G., Brunetti, A., Vecchio, L.D., Northcott, P.A., Delattre, O., Taylor, M.D., Iolascon, A., Zollo, M. PLoS. One. (2009) [Pubmed]
  2. MicroRNA expression changes during human leukemic HL-60 cell differentiation induced by 4-hydroxynonenal, a product of lipid peroxidation. Pizzimenti, S., Ferracin, M., Sabbioni, S., Toaldo, C., Pettazzoni, P., Dianzani, M.U., Negrini, M., Barrera, G. Free. Radic. Biol. Med. (2009) [Pubmed]
 
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