Disease relevance of miR-199b
Reduced expression of miR-199b-5p appears to be associated with metastatic medullobalstoma and poor prognosis for patients [1].
Expression
Detected by quantitative PCR in the cerebellum, with higher levels of expression in infants (0-1 year-olds) compared to teenagers (13-16 year-olds) [1].
High impact information on miR-199b-5p
miR-199b-5p suppresses HES1 expression, reducing proliferation and anchorage independent growth of medulloblastoma cells
Biological context of miR-199b-5p
Six miRNAs, including miR-199b-5p, were down-regulated during differentiation of HL-60 leukemic cells by 4-hydroxynonenal, a lipid peroxidation product [2].
References