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Gene Review

Rbp2  -  RNA-binding protein 2

Drosophila melanogaster

Synonyms: CG4429, Dmel\CG4429, MRE9, RRM2, anon-EST:fe1B9, ...
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Disease relevance of Rbp2

  • Remarkably, mutation of either RRM2 or the RTZF results in the same spectrum of phenotypes: mutants exhibit reduced viability, abnormal wing and mechanosensory bristle morphology, female sterility, and flightlessness [1].

High impact information on Rbp2

  • Finally, we show that mutations in RRM1, RRM2, or the RTZF do not affect the circadian regulation of eclosion, and we discuss possible interpretations of these results [1].
  • The severity of these phenotypes is similar in single mutants and double RRM2; RTZF mutants, indicating a lack of additivity for the mutations and suggesting that RRM2 and the RTZF act together, in vivo, to determine LARK function [1].


  1. Genetic analysis of functional domains within the Drosophila LARK RNA-binding protein. McNeil, G.P., Schroeder, A.J., Roberts, M.A., Jackson, F.R. Genetics (2001) [Pubmed]
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