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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

FXYD4  -  FXYD domain containing ion transport...

Homo sapiens

Synonyms: CHIF, FXYD domain-containing ion transport regulator 4, UNQ526/PRO1069
 
 
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High impact information on FXYD4

  • FXYD2 or gamma subunit and FXYD4 or CHIF modulate the apparent affinity for Na(+) of Na, K-ATPase in an opposite way, adapted to the physiological needs of Na(+) reabsorption in different segments of the renal tubule [1].
  • The nonoverlapping distribution of gamma and CHIF (FXYD4) in kidney helps to explain physiological differences in Na(+) affinity among nephron segments [2].

References

  1. Function of FXYD proteins, regulators of Na, K-ATPase. Geering, K. J. Bioenerg. Biomembr. (2005) [Pubmed]
  2. FXYD proteins as regulators of the Na,K-ATPase in the kidney. Sweadner, K.J., Arystarkhova, E., Donnet, C., Wetzel, R.K. Ann. N. Y. Acad. Sci. (2003) [Pubmed]
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