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Gene Review

PPP1R3C  -  protein phosphatase 1, regulatory subunit 3C

Homo sapiens

Synonyms: PP1 subunit R5, PPP1R5, PTG, Protein phosphatase 1 regulatory subunit 3C, Protein phosphatase 1 regulatory subunit 5, ...
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Regulatory relationships of PPP1R3C

  • We have recently described that the activity of R5/PTG is down-regulated by the laforin-malin complex, composed of a dual specificity phosphatase (laforin) and an E3-ubiquitin ligase (malin) [1].


  1. AMP-activated protein kinase phosphorylates R5/PTG, the glycogen targeting subunit of the R5/PTG-protein phosphatase 1 holoenzyme, and accelerates its down-regulation by the laforin-malin complex. Vernia, S., Solaz-Fuster, M.C., Gimeno-Alcañiz, J.V., Rubio, T., García-Haro, L., Foretz, M., de Córdoba, S.R., Sanz, P. J. Biol. Chem. (2009) [Pubmed]
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